POU4F1 and rheumatoid arthritis: We also observed upregulation of immunoglobulin genes, including the chemokine CXCL6; CHI3L, which is strongly associated with diseases such as liver fibrosis, rheumatoid arthritis, and inflammatory bowel disease [13,14,15]; POU4F1, which is a neural transcription factor; MMP10, which contributes to extracellular matrix remodeling; and IL11, which has been suggested as a therapeutic target in fibrotic diseases [16,17].