Taken together, the bulk of data may suggest that S100B might play a role as an inflammatory adipokine in the interaction between adipocytes and macrophages to establish a vicious paracrine loop (Figure 1), possibly as a part of the adipocyte/macrophage cross-talk, which has been described in obesity [61], thus reflecting the putative role played by astrocytic S100B, via microglial cells, in neuroinflammatory/neurodegenerative disorders [18]. Here, S100B is linked to Obesity.