CD4 and psoriasis: In addition, Lisa Strohbuecker et al. conducted a comprehensive study on the relationship between HMGB1 and immune cells, revealing that HMGB1 expression was markedly elevated in the psoriatic skin lesions, and its receptor RAGE expression was also significantly increased on CD8+ cells and CD4+ Treg cells within the skin lesion area, which was strongly associated with the disease progression in psoriasis [79].