Enriched KEGG terms such as “Systemic lupus erythematosus”, “Alcoholism”, “Axon guidance”, and “PI3K-Akt signaling pathway”, ranked as overrepresented terms by the downregulated NDKO DEGs, were mainly affected by REV-ERBα abrogation (Figure 4D). The gene discussed is NR1D1; the disease is alcohol dependence.