We compared PEST-mutated tumor models (CTV-1, SKW-3/KE-37, and REC-1) to WT ones (JEKO-1, Granta-519, MEC-1) and showed that cell lines carrying the PEST mutation were more sensitive to CAD204520 inhibition (Figure 2C,D) with increasing apoptosis after treatment (Figure 2E–G). This evidence concerns the gene RAD1 and neoplasm.