Hypercholesterolemia promotes platelet hyperreactivity by direct interaction of oxidized low-density lipoprotein (oxLDL) with the platelet membrane by CD-36 receptors and signaling pathways including Src family kinases (SFKs), mitogen-activated protein kinases (MAPKs), and nicotinamide adenine dinucleotide phosphate (NADPH) oxidase [52]. This evidence concerns the gene WNK2 and familial hypercholesterolemia.