MAP2K7 and central nervous system cancer: It is known that the inhibitors of proteins involved in signal transduction by RAS-RAF-MEK-ERK and PI3K-AKT/PKB-mTOR signaling pathways significantly increases the sensitivity of glioma cells to the induction of apoptosis [19,20] Therefore, in addition to a single application of furanocoumarins, they were combined with the RAF kinase inhibitor—sorafenib and the PI3K kinase inhibitor—LY294002 and the microscopic observations of characteristic morphological changes were conducted (Figure 4).