For instance, the activation of Notch2 by ligation with Jag1 and subsequent nuclear translocation of the Notch2 intracellular domain has been observed to induce bronchial epithelial dysfunction by increasing the differentiation of club cells into goblet cells rather than ciliated cells, hence promoting mucus plugs formation and airway obstruction [75]. This evidence concerns the gene NOTCH2 and Airway obstruction.