Liu et al. have demonstrated that TRPM7 activates Janus kinase 2/signal transducer and the activator of transcription 3 (JAK2/STAT3) and/or Notch signaling pathways, resulting in the activation of aldehyde dehydrogenase 1 (ALDH1) promoters and increased proliferation, migration and invasion in a human glioblastoma cell line [93]. The gene discussed is JAK2; the disease is glioblastoma.