Indeed, whereas in renal cancer and in tumors of the gastrointestinal tract, PRODH appears to induce cell cycle arrest and apoptosis as mechanisms of tumor suppression [21,22], in pancreatic ductal ADC PRODH supports nutrient-deprived pancreatic cell survival and proliferation by utilizing collagen derived proline to fuel the tricarboxylic acids cycle [20]. Here, PRODH is linked to neoplasm.