PRODH and cancer: Thus, PRODH can either suppress or promote cancer development and progression, likely depending on cell and tissue types, and on the type of stress acting on them, by exploiting the use of proline as an intermediate for the conversion to other amino acids and metabolites, whereas the electrons obtained from proline oxidation can be used to produce ATP or ROS to sustain different processes such as cell survival, autophagy, apoptosis or cellular senescence [14,33].