A CRISPRko screen conducted in the rhabdoid tumor cells G401 and G402 in presence of the enhancer of zeste homolog 2 (EZH2) inhibitor GSK126 revealed that the H3K36me2 methyltransferase nuclear receptor binding SET domain protein (NSD) 1 was connected with resistance [153]. The gene discussed is EZH2; the disease is neoplasm.