In the study of human coronary artery endothelial cells (HCAEC), it was found that TRPC3 may mediate Ca2+ influx through the CAM/CAMK signaling pathway and activate NF-κB, and via NFκB the control of VCAM-1 expression in HCAEC is involved in the pathogenesis of atherosclerosis. The gene discussed is NFKB1; the disease is atherosclerosis.