TRP channels in the liver are implicated in a variety of physiological and pathological processes, including liver regeneration (TRPM8), hepatocyte damage due to oxidative stress (e.g., TRPV4, TRPM2), liver ischemia and perfusion injury (e.g., TRPM2, TRPM6, TRPM7, TRPM8), liver fibrosis (TRPV1), and hepatocellular carcinoma (e.g., TRPC6, TRPV2), among others. Here, TRPV4 is linked to hepatocellular carcinoma.