Additional research has demonstrated that TRPM2, TRPM6, TRPM7, and TRPM8 may impact hepatic ischemia-reperfusion injury, with TRPM2 knockout exhibiting a reduction in such injury through the activation of autophagy and inhibition of autophagy-negative regulation of the NLRP3 inflammasome pathway [107,108]. Here, TRPM8 is linked to ischemia.