TRPM8 and hypertensive disorder: Various studies have indicated that distinct TRP channels may be involved in the pathogenesis of hypertension, including TRPM7 (leptin-induced hypertension), TRPV1 (cardiac sympathetic afferent reflex (CSAR) induced hypertension), TRPM5 (high-salt-induced hypertension), and TRPM8 (cold-induced hypertension).