Of special note, the best known FH-related hit, the PCSK9 gene, which promotes LDLR degradation and plays a critical role in regulating cholesterol homeostasis [47,48], shows no significant differences in expression between control and FH iPSC-ECs, and patients carry no pathogenic mutations in the gene (clinical genotyping data). The gene discussed is PCSK9; the disease is familial hyperaldosteronism.