We also found dysregulation of angiogenesis genes (XDH, SEMA5A, and SULF1) and the Rap1 pathway (ADORA2B, GNAO1, SULF1, and EFNA2), which promotes endothelial homeostasis and may be involved in endothelial dysfunction-associated cardiovascular pathologies [53]. The gene discussed is SEMA5A; the disease is endothelial dysfunction.