OGT and neoplasm: Compared to the extracellular vesicles derived from normal tissue, the vesicles derived from tumor cells were enriched in glutamine fructose-6-phosphate amidotransferase (GFAT), a crucial enzyme of the hexosamine biosynthetic pathway that results in the synthesis of uridine diphosphate N-acetylglucosamine (UDP-GlcNAc), which is a substrate for O-linked β-N-acetylglucosamine protein modification (O-GlcNAcylation) performed by O-GlcNAc transferase (OGT) [96].