STAT3 and melanoma: In the study effectuated by Cao and co-workers [123], the authors investigated the antitumor activity of quercetin on human melanoma cells (A375, and A2058), as well as on murine melanoma cells (B16F10), and showed that quercetin induces apoptosis in melanoma cells and decreases cell proliferation, migration, and invasion through the downregulation of STAT3 signaling and its targeted gene expression.