Moreover, melatonin attenuated angiotensin II-induced cardiomyocyte hypertrophy in cell culture via the CypA/CD147 signaling pathway, reducing ROS production [84], and, in Ang-IIinduced hypertension in mice, melatonin attenuated cardiac hypertrophy and improved mitochondrial function via mitochondrial calcium uptake 1 (MICU1) [85]. Here, MICU1 is linked to cardiac hypertrophy.