The frequent renal involvement with organ damage in patients with COVID-19 is undoubtedly multifactorial, but the expression on renal cells of the key receptors promoting SARS-CoV-2 entry, such as ACE2, TMPRSS2, and NRP1 can make the kidney particularly susceptible to SARS-CoV-2 infection [19,20,21]. The gene discussed is ACE2; the disease is COVID-19.