At the physiological level, ACE2 is involved in regulating blood pressure and plays a role in the renin-angiotensin-aldosterone system (RAS) where the overactivation of the RAS pathways results in hypertension, kidney damage, and cardiovascular disease, in addition to being one of the pivotal signaling in SARS-CoV-2–induced nephrotic syndrome [36]. This evidence concerns the gene ACE2 and cardiovascular disorder.