At the experimental level, Choong and colleagues analyzed the expression of ACE2, TMPRSS2, and NRP1 proteins in RCC by immunohistochemistry of tissue microarray (TMA) by using 263 cases of CCRCC, 139 of pRCC, 18 of CHRCC, and human kidney tissue as controls [28]. This evidence concerns the gene ACE2 and chromophobe renal cell carcinoma.