Another study that emphasized the adjuvant chemotherapeutic role of OLE was conducted by Ruzzolini et al. on A375 human melanoma cells, showing that OLE at a concentration of 500 μM stimulates apoptosis and that, at lower dosages (namely 250 μM), is able to interfere in cell proliferation and in the impairment of the pAKT/pS6 pathway. This evidence concerns the gene TAS2R63P and melanoma.