In acute myocardial infarction, galectin-3 increase showed a direct proportional relationship with other biomarkers (matrix metalloproteinase-3, monocyte chemoattractant protein-1, and interleukin-8) and was positively associated with infarct size and ventricular remodeling in patients with a history of complicated myocardial infarction [125]. The gene discussed is MMP3; the disease is myocardial infarction.