In this review, we focused on understanding the pathological mechanisms underlying the interaction between chronic kidney disease and ischemic heart disease, as well as the analysis of common biomarkers for both pathologies, such as cardiac troponins, natriuretic peptides, copeptin, galectin-3, FGF-23 and Klotho, sST2, and GDF-15, which have proven their diagnostic and prognostic roles. The gene discussed is FGF23; the disease is chronic kidney disease.