Curcumin has also exhibited antifibrotic potential in the heart of MI mouse models; to further understand the mechanism, LPS-stimulated Raw 264.7 cells treated with curcumin demonstrated an inhibition of inflammation through the downregulation of interleukin-1β (IL-1β), interleukin-18 (IL-18), IL-6, and TNF-α [243]. The gene discussed is IL18; the disease is myocardial infarction.