They also include side effects relating to VEGFR inhibition with hypertension, bleeding, deep venous thrombosis, arterial thrombosis, pulmonary embolism and more rare side effects including reversible posterior leukoencephalopathy syndrome, proteinuria that can lead to nephrotic syndrome, renal failure, ejection fraction decrease, heart failure, QTc prolongation, perforation, impaired wound healing, and fistula formation. This evidence concerns the gene KDR and heart failure.