The role of statins in Rett syndrome, an X-linked disease characterized by the progressive development of neurological and motor dysfunction, was suggested by a murine study conducted by Buchovecky et al., in which statins had a favorable impact on the systemic imbalance of the lipid profile, motor symptoms, and longevity in Mecp2 (methyl CpG binding protein 2) mutant mice [72]. This evidence concerns the gene MECP2 and atypical Rett syndrome.