IGHE and thyroid gland disorder: However, there was no significant difference between CSU and CIU in terms of age at admission, presence of atopy, and family history of CU as well as autoimmunity, serum-total IgE levels, presence of eosinopenia and basopenia, ANA positivity, existence of thyroid antibodies, positive autologous serum skin test, and Helicobacter pylori positivity.