However, there was no significant difference between CSU and CIU in terms of age at admission, presence of atopy, and family history of CU as well as autoimmunity, serum-total IgE levels, presence of eosinopenia and basopenia, ANA positivity, existence of thyroid antibodies, positive autologous serum skin test, and Helicobacter pylori positivity. This evidence concerns the gene IGHE and Autoimmunity.