However, after reviewing all of the important published manuscripts on NephroCheck (a cartridge-based commercial test system for the identification of AKI using biomarkers), the most promising urinary biomarkers of AKI were found to be tissue inhibitor of metalloproteinases-2 (TIMP-2) and insulin-like growth factor-binding protein 7 (IGFBP-7), although there were no clear differences between trends in NephroCheck (concentration measured or normalized to urinary creatinine excretion or urine osmolality) for AKI versus non-AKI [24,25]. Here, IGFBP7 is linked to acute kidney injury.