Recently, it was demonstrated in two genetically engineered mouse models (GEMMs) of pancreatic cancer that the TGF-β pathway is controlled by full-length, transcriptionally active p73 (TAp73), a p53 family member and close homologue [13], through regulation of Bgn secretion via intermittent Smad3/4 expression/activity [14]. This evidence concerns the gene TGFB1 and pancreatic neoplasm.