In concordance with the crucial of Bgn in mediating the tumor-suppressive effect of TAp73 in Tp73-deficient mice, we provide evidence in the present study that in human PDAC, RAC1b and TAp73α collaborate in promoting the expression of BGN and, as a consequence, inhibit basal and TGF-β-driven ERK activation and cell migration. The gene discussed is MAPK1; the disease is neoplasm.