Given the reported localization of DYRK3 to the mitotic spindle poles [8] and our observation of endogenous CAMKV and phospho-Thr246 AKT1S1 in the mitotic spindles of dividing NB cells, we hypothesize a critical role for this novel DYRK3/CAMKV/AKT1S1 module in the assembly, maintenance, or dissolution of the mitotic spindle of proliferating NB cells. This evidence concerns the gene DYRK3 and neuroblastoma.