We annotated and ranked the expression of all five DYRK kinases (DYRK-1A, 1B, 2, 3, and 4) across 10 publicly available NB patient datasets from the ‘R2: Genomics Analysis and Visualization Platform’ (as previously described [2]) and observed a significant and robust correlation between DYRK3 expression and a worse patient survival in 8 of these 10 cohorts, but not for any other family members (Figure 1). This evidence concerns the gene DYRK3 and neuroblastoma.