In all three models, there was a significant reduction in NK cell content in tumor infiltrates when tumor cells expressed sMICB (Figure 3A, p < 0.05 for all models), which is consistent with the previous finding in the TRAMP/MICB autochthonous tumor model that tumor-produced sMIC impairs the NK cell’s homeostatic self-renewal ability [36]. The gene discussed is MICB; the disease is neoplasm.