We previously demonstrated that NEU3, EGFR, and Src were co-immunoprecipitated in NEU3- and EGFR-transfected NIH-3T3 cells, and the overexpression of NEU3 could cause the constitutive activation of EGFR together with Src activation in the presence of EGF, leading to potentiation of the tumorigenicity of cancer cells [18]. Here, EGF is linked to cancer.