Indeed, NEU3 has been reported to be involved in carcinogenesis, as evident from the fact that NEU3 transgenic mice have increased azoxymethane-induced abnormal crypt foci, whereas NEU3 knockout mice show reduced tumor incidence in azoxymethane- and dextran sodium sulfate-induced colitis-associated colon carcinogenesis models [12]. This evidence concerns the gene NEU3 and digestive system neoplasm.