IDH3A and central nervous system cancer: According to the 2021 World Health Organization (WHO) Classification of Tumors of the Central Nervous System (CNS), pediatric-type diffuse high-grade gliomas are now classified into four types of tumors: diffuse midline gliomas, H3 K27 altered; diffuse hemispheric gliomas, H3 G34 mutant; diffuse pediatric-type high-grade gliomas, H3 wildtype and IDH (isocitrate dehydrogenase) wildtype; and infant-type hemispheric gliomas, each having distinct prognoses and molecular characteristics [10].