TGFB2 and neoplasm: IFNGR2 and TGFB2 expression levels were significantly higher in pbDMG tumors than in normal brainstem/pons samples, and high TGFB2 levels were linked to poor overall survival (OS) in pbDMG patients (Figure 8), regardless of the IFNGR2 levels or patients’ age; therefore, the abrogation of TGFB2 mRNA expression in the immunologically cold tumor microenvironment may help to treat pbDMG patients.