By comparing the TSPO radioligand uptake of GL261 in TSPO+/+ and TSPO−/− mice, Banati et al. found that the TSPO PET signal extended beyond the tumor in TSPO+/+ mice as opposed to TSPO−/− mice, thus heavily supporting the assumption of a relevant inflammatory component to the TSPO signal [37]. The gene discussed is TSPO; the disease is neoplasm.