The UV light-activatable gene editing RNAs (UA-RNA), hybridized with single-guided RNA (sgRNA) and UV-labile linker-modified complementary sequences, were dehybridized upon UV irradiation, activating the CRISPR/Cas13d system to cleave multidrug resistance-associated protein 1 (MRP1) mRNA, resulting in the downregulation of multi-drug resistance (MDR) in tumor cells and increased sensitization to chemo drugs. The gene discussed is ABCC1; the disease is neoplasm.