In animal models of anxiety and depression, female mice exhibiting depressive behaviors, elevated inflammatory cytokines (such as TNF-α and IL-1β), and HPA axis activation, but reduced transcription of c-fos and AVP indicate that inflammatory factors may disrupt the balance of the HPA axis by inhibiting the transcription of c-fos and AVP [114]. The gene discussed is IL1B; the disease is major depressive disorder.