Late-septic patients have changes in GPR18 expression on their immune cells compared with non-septic patients. Changes to GPR18 expression suggests that there is decreased specialized pro-resolving mediator (SPM) bioavailability and uncoupled inflammation resolution circuits.Increased GPR18 expression on monocytes and decreased GPR18 expression on neutrophils is correlated with an increase in mortality due to sepsis. This evidence concerns the gene GPR18 and Sepsis.