This additional example of peculiar alterations of specific immune cells (like basophils) compared to another rheumatic disorder led us to speculate about the immunopathological relevance of these changes, also considering the respective potential contribution of both basophils and DNT cells in the promotion of Th2-skewed immune response (also by producing IL-4) [68,69] and autoantibody production (by supporting B cells) [23,34], according to both general and specific evidence in mice. This evidence concerns the gene IL4 and rheumatic disorder.