The identification and exploration of biomarkers such as GLP-1, GIP, MCP-1, and IGFBP-7 have provided valuable insights into the complex pathophysiology of metabolic disorders, including type 2 diabetes and obesity [1,2,3,4,5,6,7,8,9]. The gene discussed is IGFBP7; the disease is obesity due to melanocortin 4 receptor deficiency.