-Impairment of translational fidelity and increased IRES-dependent translation of p27 tumor suppressor, XIAP, TP53, CDKN1B, and BCL2L1 [30,71,75].-Lymph node metastasis at diagnosis, vascular infiltration by tumor cells, p53 accumulation, and BCL-2 and EGFR expression [13]. The gene discussed is CDKN1B; the disease is neoplasm.