Bcl3 is known to regulate the NF-κB mediated transcription of genes associated with both apoptosis and proliferation such as Bcl-2, Cyclin D1 and STAT3 [25,26,27,28], and has been implicated with maintaining breast cancer cell survival following DNA damage through both p53-dependent and -independent pathways [29,30]. The gene discussed is NFKB1; the disease is breast cancer.