TLR7 and rheumatoid arthritis: Endogenous TLR7 ligands (ssRNA and miR-let7b) were elevated in RA synovial fluid and the miR-Let7b/TLR7 pathway was found to foster metabolic malfunction in RA macrophages and FLSs, promote osteoclastogenesis, and potentiate murine synovitis [96,97].