In a model of collagen-induced arthritis, global knock-out of TLR4, although it had no inhibitory effect in the systemic production of proinflammatory mediators and anti-collagen antibody production, reduced the incidence and severity of arthritis, protected from cartilage damage, and decreased the levels of antibodies against citrullinated peptides (anti-CCP) [76]. This evidence concerns the gene TLR4 and arthritic joint disease.