TLR7 and systemic lupus erythematosus: Four small molecules, dual inhibitors of TLR7 and TLR8 (Afimetoran/BMS-986256, Enpatoran/M5049, MHV370, and E6742), have successfully passed the stage of preclinical validation in various murine models of lupus and recently entered the early phases of clinical development in humans [47,48,49,50,51,52,53,54,55,56,57].