Moreover, verteporfin, an inhibitor of YAP1, reduces the S1P-induced proliferation of pulmonary arterial smooth muscle cells and hypoxia-induced pulmonary arterial hypertension [126], indicating that YAP1 is associated with the development of SphK1-induced pulmonary hypertension. The gene discussed is SPHK1; the disease is pulmonary arterial hypertension.