A study in miR-146b-knockout mice showed that they developed AML or B-cell lymphoma, probably due to the alteration of the NF-kB pathway by inhibiting TNF receptor-associated factor 6 (TRAF6) and interleukin-1 receptor-associated kinase 1 (IRAK1) [78]. This evidence concerns the gene NFKB1 and acute myeloid leukemia.