Similarly, when associated with liposomal formulation in K-562 and K-562 Lucena (MDR+) tumor cells, a reduction in mitochondrial electrical potential, Bcl-2, increased expression of the pro-apoptotic proteins BAD, BAX, and phosphorylated caspase 3 and 8, as well as Cytochrome c release in the cytoplasm were observed27. This evidence concerns the gene CYCS and neoplasm.