The results showed that LRGT caused the marked reduction in brain atrophy in the diabetic (db/db) and the APP/PS1xdb/db mice, as well as reduced Aβ aggregates levels (p = 0.046) and tau hyperphosphorylation (p = 0.009) in the APP/PS1xdb/db mice [100]. This evidence concerns the gene APP and Brain atrophy.