Fats are related to AD in other ways as well, with high-fat diets leading to the release of inflammatory markers at the hypothalamus, triggering the c-Jun N-terminal kinase (JNK) pathway to increase the activation of the leptin and insulin signaling inhibitor nuclear factor kappa-light-chain-enhancer of activated B cells [66,67]. The gene discussed is MAPK8; the disease is Alzheimer disease.