Our findings have shown the unit area of MMP-2 expression increases in the glandular component of the endometrium with endometriosis in comparison to the control group, which may indicate an increased activity of MMP-2 in the case of pathology and is consistent with the literature data on the increased activity of matrixins in extragenital endometriosis development [36,37]. This evidence concerns the gene MMP2 and endometriosis.