Its importance was understood by designing siRNA against BMP3 in RA patients, which revealed that inhibition of BMP expression augments the synthesis of proinflammatory cytokines such as IL-6, IL-1β, TNF-α, and IL-17A and chemokines such as CCL-2 and CCL-3, along with MMP-3 and MMP-9 [40]. The gene discussed is TNF; the disease is rheumatoid arthritis.