Because of these characteristics, when combined with a variety of drugs and biomolecules, such as siRNA, porous silica nanoparticles can be exploited as a nanocarrier system for these molecules in the tissue of interest.A mesoporous bioactive glass (MBG) nanosphere composed of silica nanoparticles was constructed to deliver receptor activator of nuclear factor-kappa beta (RANK) siRNA to the monocyte macrophage cell line RAW 264.7 of mice and osteoclast precursors in vitro to design a therapy for osteoporosis. The gene discussed is TNFRSF11A; the disease is osteoporosis.