An analysis of 195 patients with B-ALL enrolled in the Nordic Society of Paediatric Haematology and Oncology (NOPHO) studies of ALL in 1992, 2000, and 2008 reported two in-frame gene fusions involving IKZF1, IKZF1::SETD5, and IKZF1::NUTM1, both retaining the DNA-binding domains of IKAROS [42,43]. This evidence concerns the gene IKZF1 and acute lymphoblastic leukemia.