To study the extent to which the mouse model reflects the human SLE disease, a comparison of the up-DPpGCs in Pla-KO1l3 vs. Pla-WT and the up-DPpGCs in SLE patients with DNASE1L3 deficiency vs. healthy controls has been implemented. Here, DNASE1L3 is linked to systemic lupus erythematosus.