THBS1 and Familial prostate cancer: For example, thrombospondins (THBS) are ECM glycoproteins involved in the inhibition of angiogenesis that were shown to regulate the normal prostate in vivo [76], but also to potentiate the cell migration and development of advanced prostate tumors (THBS1) [77] and prostate cancer bone metastasis (THBS2) [78].