Furthermore, integrins α4 [92] and α4β1 [93] have been implicated in the adherence of prostate cancer cells to the bone marrow endothelium, while integrins α5β1 [94] and α9 [95] were shown to be involved in the interactions of prostate cancer cells with the bone microenvironment. This evidence concerns the gene IGKV1D-22 and Familial prostate cancer.