Namely, the AR, in interaction with ITGB1 and membrane type-matrix metalloproteinase 1 (MT-MMP-1 or MMP14), activates a protease cascade triggering ECM remodeling, which facilitates the cancer-associated fibroblast invasion through the ECM and a subsequent interaction with prostate cancer cells [59]. This evidence concerns the gene MMP14 and Familial prostate cancer.