Other bone formation (BGLAP (osteocalcin) and SPP1 (osteopontin)) and bone resorption (IBSP (integrin-binding sialoprotein or bone sialoprotein)) ECM glycoproteins were also explored for their biomarker potential in prostate cancer metastasis formation and are discussed in more detail in [123]. The gene discussed is SPP1; the disease is Familial prostate cancer.