Furthermore, since the αVβ5 integrin heterodimer is among the most studied integrins, the additional four proteins (talin 2 (TLN2), filamin A and B (FLNA, FLNB), and plectin (PLEC)) that were shown to be part of its adhesome [14] were analyzed for their potential roles in prostate cancer biomarker discovery. This evidence concerns the gene TLN2 and Familial prostate cancer.