In OLP, keratinocyte apoptosis is induced by T lymphocyte-mediated cytotoxicity; the majority of T lymphocytes next to the injured basal keratinocytes are CD8+ T-cells which may directly interact with major histocompatibility complex-1 on keratinocytes, leading to chemokine release and other immune cell recruitment, finally causing the formation of OLP lesions [94]. Here, CD8A is linked to oral lichen planus.