Furthermore, in vivo studies using a Hbα mimetic peptide have shown that competitively uncoupling Hbα from eNOS results in increased NO signaling in the vessel wall, decreased alpha-1-adrenergic vasoconstriction, lower mean arterial blood pressure, and protection against angiotensin-2 induced hypertension in mice [17,18]. This evidence concerns the gene AGT and hypertensive disorder.