Compared to previous studies analyzing the levels of cell adhesion molecules in those who did or did not present CV events over several years [9,47], we showed that VCAM-1 was associated with a high cardiovascular risk predicted by the SCORE-2 and SCORE-2OP risk tools in OSA patients, supporting its use as a marker of CVR and bridging the gap in the knowledge. The gene discussed is VCAM1; the disease is obstructive sleep apnea syndrome.